4-Coumaric acid → HCID 11288952, compound

Participants

Reaction Steps

4-hydroxy-cinnamic acid (4.21 g, 25.67 mmol) and imidazole (5.24 g, 77.01 mmol) were charged in a 250 mL round-bottom flask and dissolved in 25 mL of dimethylformamide. Tert-butyldimethylsilyl chloride (8.12 g, 83.90 mmol) was added thereto at 0° C., followed by stirring for 30 minutes. The reaction liquid was concentrated by distillation under reduced pressure and dichloromethane (50 mL) was added thereto, followed by washing with water. The organic layer was dried over anhydrous magnesium sulfate, concentrated and dissolved in tetrahydrofuran (114 mL)/methanol (322 mL), and a 0.00035M potassium carbonate aqueous solution (120 mL) was added thereto, followed by stirring for 1 hour. After being concentrated by distillation under reduced pressure, the resulting solid was filtered, washed with water, and dried under vacuum to afford the title compound.

Provenance & Evidence