Acetonitrile → HCID 70663854, compound

Participants

Reaction Steps

Trans-ethyl(4-hydroxy-3-methoxy)cinnamate (222 mg, 1 mmol, manufactured by Fluka), acetonitrile (156 μL, 3 mmol), 1M lithium bis(trimethylsilyl)amide (3 mL, 3 mmol) and tetrahydrofuran (3 mL) were stirred at room temperature for 30 minutes. A saturated ammonium chloride aqueous solution (15 mL) and ethyl acetate (10 mL) were added thereto, followed by separation of layers into two layers and washing with distilled water and saline. The organic layer was dried over anhydrous sodium sulfate and separated by column chromatography (n-Hex/EtOAc=3/1 (v/v)) to afford Compound 10.

Provenance & Evidence