HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 147873467, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 88876342 | HCID 88876342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 147873467 | HCID 147873467 | — |
Reaction Steps
To a solution of compound of example 10 (10 mg) in dichloromethane (2 mL) dicyclohexylcarbodiimide (3 mg), and HOBt (2 mg) were added. After 20 min. 4-fluoro benzyl amine (1.5 mg) was added, The reaction mixture was stirred for 18 h under nitrogen atmosphere. Cold water was added to the reaction mixture, the organic layer was separated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637683B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-07b086fcfc1f4b3bb0cadef75f18bff0 |
| Source note | uspto-grants-2014_01 |