4-(Difluoromethyl)-3-iodobenzoic acid → HCID 58349703, compound

HRID 476241Notes

Reaction equation

HRID 476241 reaction equation
[F:1][CH:2]([F:13])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1[I:12].[CH3:14][NH:15][C@H:16]1[CH2:35][N:20]2[C:21]3[C:26]([C:27]([CH2:28][C:29]([O:31]CCC)=[O:30])=[C:19]2[CH2:18][CH2:17]1)=[CH:25][CH:24]=[CH:23][CH:22]=3>>[F:13][CH:2]([F:1])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:15]([CH3:14])[C@H:16]2[CH2:35][N:20]3[C:21]4[C:26]([C:27]([CH2:28][C:29]([OH:31])=[O:30])=[C:19]3[CH2:18][CH2:17]2)=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:9])=[CH:5][C:4]=1[I:12]

Participants

3

Reactant 2

HCID 448285224-(Difluoromethyl)-3-iodobenzoic acidHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 58349703HCID 58349703, compound

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from 4-(difluoromethyl)-3-iodobenzoic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 539.

Sources & evidence

ORD record
ord-06dc61f4bd484990a1f55b22844fd902
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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