4-Fluorobenzoyl chloride → HCID 54582719, compound

HRID 476242Notes

Reaction equation

HRID 476242 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][NH:12][C@H:13]1[CH2:32][N:17]2[C:18]3[C:23]([C:24]([CH2:25][C:26]([O:28]CCC)=[O:27])=[C:16]2[CH2:15][CH2:14]1)=[CH:22][CH:21]=[CH:20][CH:19]=3>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]([CH3:11])[C@H:13]2[CH2:32][N:17]3[C:18]4[C:23]([C:24]([CH2:25][C:26]([OH:28])=[O:27])=[C:16]3[CH2:15][CH2:14]2)=[CH:22][CH:21]=[CH:20][CH:19]=4)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 54582719HCID 54582719, compound

Procedure

The title compound was prepared using analogous procedures described in Example 2 (Method B) from 4-fluorobenzoyl chloride and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 381.

Sources & evidence

ORD record
ord-d81bc49b093e4545b75404747b80b004
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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