1-(4-fluorophenyl)cyclopropanecarboxylic acid → HCID 54587623, compound

HRID 476256Notes

Reaction equation

HRID 476256 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:14][NH:15][C@H:16]1[CH2:35][N:20]2[C:21]3[C:26]([C:27]([CH2:28][C:29]([O:31]CCC)=[O:30])=[C:19]2[CH2:18][CH2:17]1)=[CH:25][CH:24]=[CH:23][CH:22]=3>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]([N:15]([CH3:14])[C@H:16]3[CH2:35][N:20]4[C:21]5[C:26]([C:27]([CH2:28][C:29]([OH:31])=[O:30])=[C:19]4[CH2:18][CH2:17]3)=[CH:25][CH:24]=[CH:23][CH:22]=5)=[O:13])[CH2:9][CH2:10]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 64842201-(4-fluorophenyl)cyclopropanecarboxylic acidHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 54587623HCID 54587623, compound

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from 1-(4-fluorophenyl)cyclopropanecarboxylic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 321.

Sources & evidence

ORD record
ord-3abc53819c174920af79a59785eaef17
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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