2,2-Bis(4-fluorophenyl)acetic acid → HCID 58349695, compound

HRID 476264Notes

Reaction equation

HRID 476264 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH3:19][NH:20][C@H:21]1[CH2:40][N:25]2[C:26]3[C:31]([C:32]([CH2:33][C:34]([O:36]CCC)=[O:35])=[C:24]2[CH2:23][CH2:22]1)=[CH:30][CH:29]=[CH:28][CH:27]=3>>[F:18][C:15]1[CH:16]=[CH:17][C:12]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:9]([N:20]([CH3:19])[C@H:21]2[CH2:40][N:25]3[C:26]4[C:31]([C:32]([CH2:33][C:34]([OH:36])=[O:35])=[C:24]3[CH2:23][CH2:22]2)=[CH:30][CH:29]=[CH:28][CH:27]=4)=[O:11])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 135116842,2-Bis(4-fluorophenyl)acetic acidHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 58349695HCID 58349695, compound

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from bis(4-fluorophenyl)acetic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 489.

Sources & evidence

ORD record
ord-aa52b079db9740eaa3631deb54180bc8
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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