propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate → HCID 58349674, compound

HRID 476269Notes

Reaction equation

HRID 476269 reaction equation
[CH2:1]([C:3]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].[CH3:16][NH:17][C@H:18]1[CH2:37][N:22]2[C:23]3[C:28]([C:29]([CH2:30][C:31]([O:33]CCC)=[O:32])=[C:21]2[CH2:20][CH2:19]1)=[CH:27][CH:26]=[CH:25][CH:24]=3>>[CH2:1]([C:3]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)([CH2:7][CH3:8])[C:4]([N:17]([CH3:16])[C@H:18]1[CH2:37][N:22]2[C:23]3[C:28]([C:29]([CH2:30][C:31]([OH:33])=[O:32])=[C:21]2[CH2:20][CH2:19]1)=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetateHCID 86655418HCID 86655418, compound

Product 1

HCID 58349674HCID 58349674, compound

Procedure

The title compound was prepared using analogous procedures described in Example 2 (Method B) from 2-ethyl-2-(4-fluorophenyl)butanoyl chloride and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido [1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 451.

Sources & evidence

ORD record
ord-b3bcb3768de3441b96eeb75f8b6906f6
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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