1-(4-fluorophenyl)cyclopropanecarboxylic acid → HCID 58349694, compound

HRID 476273Notes

Reaction equation

HRID 476273 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH2:14]([NH:16][C@H:17]1[CH2:36][N:21]2[C:22]3[C:27]([C:28]([CH2:29][C:30]([O:32]CCC)=[O:31])=[C:20]2[CH2:19][CH2:18]1)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:15]>>[CH2:14]([N:16]([C:11]([C:8]1([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1)=[O:13])[C@H:17]1[CH2:36][N:21]2[C:22]3[C:27]([C:28]([CH2:29][C:30]([OH:32])=[O:31])=[C:20]2[CH2:19][CH2:18]1)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:15]

Participants

3

Reactant 2

HCID 64842201-(4-fluorophenyl)cyclopropanecarboxylic acidHCID 86655419HCID 86655419, compound

Product 1

HCID 58349694HCID 58349694, compound

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from 1-(4-fluorophenyl)cyclopropanecarboxylic acid and propyl [(7R)-7-(ethylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 435.

Sources & evidence

ORD record
ord-2a320cf262124ed2a825df0891553fe7
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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