1-Benzocyclobutenecarboxylic acid → HCID 54581746, compound

HRID 476275Notes

Reaction equation

HRID 476275 reaction equation
[C:1]12[CH2:8][CH:7]([C:9]([OH:11])=O)[C:6]1=[CH:5][CH:4]=[CH:3][CH:2]=2.[CH3:12][NH:13][C@H:14]1[CH2:33][N:18]2[C:19]3[C:24]([C:25]([CH2:26][C:27]([O:29]CCC)=[O:28])=[C:17]2[CH2:16][CH2:15]1)=[CH:23][CH:22]=[CH:21][CH:20]=3>>[C:1]12[CH2:8][CH:7]([C:9]([N:13]([CH3:12])[C@H:14]3[CH2:33][N:18]4[C:19]5[C:24]([C:25]([CH2:26][C:27]([OH:29])=[O:28])=[C:17]4[CH2:16][CH2:15]3)=[CH:23][CH:22]=[CH:21][CH:20]=5)=[O:11])[C:6]1=[CH:5][CH:4]=[CH:3][CH:2]=2

Participants

3

Reactant 2

HCID 3023241-Benzocyclobutenecarboxylic acidHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 54581746HCID 54581746, compound

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 389.

Sources & evidence

ORD record
ord-825c15568bc34f1faf3e7c54fa32145f
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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