Diisopropylethylamine → HCID 90901986, compound

Participants

Reaction Steps

DIPEA (0.43 mL, 25 mmol) and diphenylphosphonic azide (489 μL, 2.3 mmol) were added to a solution of 3-(2′-t-butoxycarbonylbiphenyl-4-ylmethyl)-7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid (1.0 g, 2.1 mmol; prepared as described in Preparation 3) in DMF (15 mL). The mixture was stirred at room temperature for 16 hours, diluted with saturated aqueous NaCl (100 mL), then extracted with EtOAc (200 mL). The organic layer was evaporated to dryness to yield crude Intermediate (10a). MS m/z: [M+H+] calcd for C30H31N5O3, 510.2. found 510.6.

Provenance & Evidence