反应详情

A mixture of N-(4-(2-(4-methoxybenzylamino)pyridin-4-yloxy)-2-fluorophenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (160 mg, 0.29 mmol) in CH2Cl2 (0.2 mL) was treated with trifluoroacetic acid (0.4 mL, 5.26 mmol) and the resultant mixture was stirred overnight at RT. The reaction mixture was concentrated to dryness and the residue was purified by reverse-phase silica gel chromatography (25-95% acetonitrile in water, 0.1% TFA). The desired fractions were partitioned between saturated aqueous NaHCO3 and EtOAc. The organics were washed with saturated aqueous NaHCO3, water, and brine and were dried over Na2SO4 and concentrated in vacuo to provide N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (52 mg, 39% yield). MS (ESI) m/z: 425.1 (M+H+).

1. concentrationThe reaction mixture was concentrated to dryness
2. customthe residue was purified by reverse-phase silica gel chromatography (25-95% acetonitrile in water, 0.1% TFA)
3. customThe desired fractions were partitioned between saturated aqueous NaHCO3 and EtOAc
4. washThe organics were washed with saturated aqueous NaHCO3, water, and brine
5. dry with materialwere dried over Na2SO4
6. concentrationconcentrated in vacuo