HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 86762272, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Thiazole | HCID 9256 | — |
| Reactant | 1,1-Dimethylethyl 2-thiazolecarboxylate | HCID 18962487 | — |
| Reactant | HCID 59799091 | HCID 59799091 | — |
| Product | HCID 86762272 | HCID 86762272 | 52% |
Reaction Steps
The Boc thiazole dimer (40) (0.281 g, 0.71 mmol) was deprotected using 95% TFA as described in general procedure D. The resulting residue (40′) was dissolved in dry DMF (5 mL) and the Boc protected thiazole acid (37) (0.172 g, 0.71 mmol) was added and reacted as described in general procedure B. This yielded a yellow foam 0.193 g (52%). LCMS (method 1) rt=3.88 min; m/z (ES+) 524 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637664B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-4b9186a6bdaf4e7f8ce032ada9aa6ae5 |
| Source note | uspto-grants-2014_01 |