反应详情

To a solution of 7-fluoro-4-propargyl-2H-1,4-benzoxazin-3(4H)-on-6-ylhydrazine (2.5 g) and enaminoxime (2.5 g) in ethanol (50 g), acetic acid (0.1 g) was added, and the resultant mixture was heated under reflux for 3 hours. After completion of the reaction, water was added to the reaction mixture, and the precipitated crystals were collected by filtration and washed with ether to give 2-[2-(7-fluoro-4-propargyl-2H-1,4-benzoxazin-3(4H)-on-6-yl)hydrazino]cyclohexanone oxime (4.0 g).

1. temperatureunder reflux for 3 hours
2. additionwas added to the reaction mixture
3. filtrationthe precipitated crystals were collected by filtration
4. washwashed with ether