Pyridine → HCID 14517946, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[2-(7-fluoro-2H-1,4-benzoxazin-3(4H)-on-6-yl)hydrazino]cyclohexanone oxime (3.0 g) in tetrahydrofuran (100 ml), 15% aqueous pyridine (60 g) was added, and a solution of copper sulfate (6 g) in water (10 ml) was added thereto, followed by heating at 80° C. for 2 hours. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with 10% aqueous copper sulfate solution, dried and concentrated. The residue was purified by silica gel column chromatography using ethyl acetate as an eluent to give 2-(7-fluoro-2H-1,4-benzoxazin-3(4H)-on-6-yl)-4,5,6,7-tetrahydro-1,2,3-benzotriazole-1-oxide. m.p., 219°-221° C.

Provenance & Evidence