Acetic Anhydride → HCID 15118095, compound

Participants

Reaction Conditions

Reaction Steps

In this example, a catalytic amount (about 4 drops) of concentrated sulfuric acid was added to a suspension of 3.5 g of (N-methyl-3-trifluoromethylbenzylsulfonamido)-acetamide in 7 mls (7.6 g) of acetic anhydride at room temperature. The mixture was heated for 2 hours at about 138° C. and then poured into ice water and extracted into methylene chloride. The methylene chloride extract was washed with aqueous 5 wt.% sodium bicarbonate solution, dried over magnesium sulfate and evaporated to dryness affording 3.4 g of a white solid. The solid was triturated with ethyl ether affording 2.17 g of the title compound.

Provenance & Evidence