Sodium Hydroxide → HCID 86743540, compound

Participants

Reaction Steps

To a flask equipped with stirrer and thermometer was added at ambient temperature 50.0 g. distilled water 7.2 g. sodium hydroxide solution (50%) and 13.3 g. (0.069 m) p-toluenesulfonic acid monohydrate, [C6H4 (CH3)-SO3H]. The mixture was stirred at ambient temperature for about 0.5 hour, after which 30.0 g. (0.069 m) octadecyldimethyl N-[(2-pyrrolidonyl) methyl]ammonium chloride was added. The reaction mixture was heated to 40°-45° to ensure complete solution and stirring continued for an additional 2 hours. The reaction was then cooled to 10°-15° C. to precipitate the crude tosylate salt product. The crude product was filtered to recover 19.8 g. of white solid product, which product was found to have 98.2% quaternized product, 0.4% amine, and 0.04% chloride. The above solid was heated in a 50° oven for 30 days and showed no loss of activity.

Provenance & Evidence