1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

Participants

Reaction Steps

A suspension of 4-acetyl-1-(4-nitrophenyl)piperazine [C. A., 67, P101031Z] (30 g, 0.12 mole) and Raney nickel (2.5 g) in ethanol (500 ml) was hydrogenated at 60 psi (414 kPa) and 40° for 6 hours followed by 18 hours at room temperature. The catalyst was subsequently removed by filtration, the solvent removed under reduced pressure and the residue crystallized from ethyl acetate to yield the title compound, m.p. 129°-130° (18.4 g, 71%), which was used directly in the next stage.

Provenance & Evidence