Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chlorothiazolo[5,4-b]pyridin-2(1H)-one | HCID 2747576 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14098030 | HCID 14098030 | 98.7% |
Reaction Steps
Methyl chloroacetate (9.6 g) and potassium carbonate (11.1 g) were added to a solution of 6-chloro-2-oxo-1,2-dihydrothiazolo[5,4-b]pyridine (15.0 g) in dry N,N-dimethylformamide (50 ml). The mixture was stirred for 30 minutes at 80° C. and then poured into cold water. The precipitates were collected by filtration, washed with water and dried over phosphorus pentoxide to give white power of 6-chloro-1-methoxycarbonylmethyl-2-oxo-1,2-dihydrothiazolo[5,4-b]pyridine (20.52 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04885297 |
|---|
| Source dataset | uspto-grants-1989_12 |
|---|
| ORD ID | ord-2329adf45ee749c08f7f186289bc5289 |
|---|
| Source note | uspto-grants-1989_12 |
|---|
