1-(2-Hydroxyethyl)piperazine → HCID 14423121, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-1-methoxycarbonylmethyl-2-oxo-1,2-dihydrothiazolo[5,4-b]pyridine (10.32 g) and N-(2-hydroxyethyl)piperazine (10.4 g) was heated at 130° C. for 15 min. After cooling, the reaction mixture was poured into an ice-water. The precipitates obtained were extracted with chloroform. The chloroform layer was dried over magnesium sulfate, and evaporated to give crude material. The crude material was purified on a silica gel column chromatography using a mixture of methylene chloride and methanol (10:1). The desired fractions containing the objective compound were collected and evaporated. The crude crystals obtained were recrystallized from a mixture of methanol and diethyl ether to give 6-chloro-2-oxo-1-{[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl}-1,2-dihydrothiazolo[5,4-b]pyridine (5.70 g).

Provenance & Evidence