1-Methylpiperazine → HCID 14423122, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-1-methoxycarbonylmethyl-2-oxo-1,2-dihydrothiazolo[5,4-b]pyridine (2.0 g) and N-methyl-piperazine (1.6 g) was heated at 130° C. for 15 min. After cooling, the mixture was purified on a silica gel column chromatography using a mixture of chloroform and methanol (10:1). The desired fractions containing the objective compound were collected and evaporated. The crude crystals obtained were recrystallized from a mixture of chloroform and diethyl ether to give 6-chloro-2-oxo-1-[(4-methyl-1-piperazinyl)carbonylmethyl]-1,2-dihydrothiazolo[5,4-b]pyridine (0.4 g).

Provenance & Evidence