Thionyl Chloride → HCID 19838006, compound

HRID 476583Notes

Reaction equation

HRID 476583 reaction equation
S(Cl)([Cl:3])=O.[O:5]=[C:6]1[C:10]([CH2:14][C:15](O)=[O:16])([CH2:11][CH2:12][CH3:13])[C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=2[O:7]1>C1C=CC=CC=1>[O:5]=[C:6]1[C:10]([CH2:14][C:15]([Cl:3])=[O:16])([CH2:11][CH2:12][CH3:13])[C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=2[O:7]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19838010HCID 19838010, compound

Product 1

HCID 19838006HCID 19838006, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

23.7 g of double-distilled thionyl chloride are added dropwise to a solution, stirred and heated to 70° C., of 23.4 g of (2,3-dihydro-2-oxo-3-propyl-3-benzofuranyl)acetic acid in 250 ml of anhydrous benzene. When the addition is complete, the mixture is heated until the evolution of gas has completely ceased. The medium is concentrated under vacuum, the residue washed with 200 ml of anhydrous benzene and the solvent evaporated off. This operation is repeated twice, and a very thick oil which does not crystallize is obtained.

Workup

  1. additionWhen the addition
  2. temperaturethe mixture is heated until the evolution of gas
  3. concentrationThe medium is concentrated under vacuum
  4. washthe residue washed with 200 ml of anhydrous benzene
  5. customthe solvent evaporated off
  6. customa very thick oil which does not crystallize
  7. customis obtained

Sources & evidence

ORD record
ord-17da71ef9b284d2dbf62646dee2cae98
Source dataset
uspto-grants-1989_12
Patent number
US04885299

Reaction notes

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