Formamidine acetate → HCID 18409955, compound

HRID 476594Notes

Reaction equation

HRID 476594 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][CH2:18][CH3:19])[NH:5][C:6](=[O:9])[C:7]=1[NH2:8].[C:20](O)(=O)C.C(N)=N.C([O-])(=O)C.[Na+]>C(O)C>[CH2:17]([O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:4]1[N:3]=[C:2]2[C:7](=[N:8][CH:20]=[N:1]2)[C:6](=[O:9])[N:5]=1)[CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 160693Formamidine acetateHCID 517045Sodium AcetateHCID 1357098565,6-Diamino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

Product 1

HCID 18409955HCID 18409955, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (0.3 g), formamidine acetate (0.18 g) and anhydrous sodium acetate (0.1 g) was heated in an oil bath at 155°-165° C. for 21/2 hours. The mixture melted and then resolidified. Ethanol (1 ml) was added and the title compound was collected by filtration, 0.31 g, m.p. 256°-258° C.

Workup

  1. temperaturewas heated in an oil bath at 155°-165° C. for 21/2 hours
  2. filtrationthe title compound was collected by filtration, 0.31 g, m.p. 256°-258° C.

Sources & evidence

ORD record
ord-6049d8013766439c90e44aba41fda1cc
Source dataset
uspto-grants-1989_12
Patent number
US04885301

Reaction notes

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