HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 13563150, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (2S)-2-[(4-Methylbenzene-1-sulfonyl)oxy]propanoic acid | HCID 12761562 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13563150 | HCID 13563150 | — |
Reaction Steps
Add 2(S)-(p-toluenesulfonyloxy)propionic acid (4.4 g) to a cold solution of 10 ml of isobutylene and 0.4 ml of concentrated sulfuric acid in 30 ml of methylene chloride in a pressure vessel, seal, and agitate at room temperature for 48 hours. Pour into 50 ml of 15% sodium carbonate solution, dry over magnesium sulfate and concentrate to obtain t-butyl 2(S)-(p-toluenesulfonyloxy)propionate as an oil (NMR δ 1.37). Distilled material (Kugelrohr, 120°) has [α]D26 =-45.9° (EtOH, c=1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04885293 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-c067ce2deec54cb5b640a81e7af7cc60 |
| Source note | uspto-grants-1989_12 |