Potassium Hydroxide → HCID 14577394, compound

HRID 476634Notes

Reaction equation

HRID 476634 reaction equation
[OH-].[K+].CC1C=C(C=CC=1)C([O:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)[CH2:13][CH2:12]1)=O>C(O)C.O>[CH3:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[C:17]([N:14]1[CH2:15][CH2:16][CH:11]([CH2:10][OH:9])[CH2:12][CH2:13]1)=[O:25]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 14577393HCID 14577393, compound

Product 1

HCID 14577394HCID 14577394, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 12.76 g (0.23 mol) of potassium hydroxide in 75 ml of ethanol and 75 ml of water is added to a solution of 80 g (0.23 mol) of [1-(3-methylbenzoyl)-4-piperidyl]methyl 3-methylbenzoate in 400 ml of ethanol. The mixture is stirred at 20° C. for 3 h, the solvent evaporated off under reduced pressure and the aqueous phase extracted with ethyl acetate. The organic phase is washed with water and then with saturated aqueous sodium chloride solution, and dried over magnesium sulphate. The solvent is evaporated off under reduced pressure and 53 g of alcohol are obtained, this being used without further treatment in the following stage.

Workup

  1. customthe solvent evaporated off under reduced pressure
  2. extractionthe aqueous phase extracted with ethyl acetate
  3. washThe organic phase is washed with water
  4. dry with materialwith saturated aqueous sodium chloride solution, and dried over magnesium sulphate
  5. customThe solvent is evaporated off under reduced pressure and 53 g of alcohol
  6. customare obtained

Sources & evidence

ORD record
ord-a0b7f871073d491d9089f83518d8dcd2
Source dataset
uspto-grants-1989_12
Patent number
US04885302

Reaction notes

Loading…