Cyclohexane → HCID 19838073, compound

HRID 476647Notes

Reaction equation

HRID 476647 reaction equation
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1.[CH2:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([O:1][CH:2]2[NH:6][C:5](=[O:7])[CH:4]=[CH:3]2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 8078CyclohexaneHCID 35354987710-47-2

Product 1

HCID 19838073HCID 19838073, compound

Conditions

Temperature
90 °C

Procedure

A mixture of 5 g of 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one in 150 cm3 of cyclohexane with 2.5 g of Amberlite IR 120 H is heated to 90° C. for 3 hours. After filtering, evaporating the solvent under reduced pressure and chromatographing the residue on silica (eluent: ethyl acetate-n-hexane, 1--1), 4.98 g of the expected product is obtained. m.p. 65°-66° C.

Workup

  1. filtrationAfter filtering
  2. customevaporating the solvent under reduced pressure and chromatographing the residue on silica (eluent: ethyl acetate-n-hexane, 1--1)

Sources & evidence

ORD record
ord-5e8fbe7570e546479bec65060e97f816
Source dataset
uspto-grants-1989_12
Patent number
US04885307

Reaction notes

Loading…