HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 19838041, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (6,8a-Dimethoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl hydrogen carbonimidate | HCID 159845 | — |
| Solvent | Furfurylamine | HCID 3438 | — |
| Product | HCID 19838041 | HCID 19838041 | 55.7% |
Reaction Steps
To a solution of 50 mg (0.13 mmol) of N-methylmitomycin A in 6 ml of anhydrous methanol, 0.5 ml of furfurylamine was added with stirring. The solvent was removed by evaporation under reduced pressure and the residue was chromatographed using silica-gel as adsorbent. The fraction obtained by eluting the column with a mixture of chloroform and ethyl acetate (1:1 by volume) was evaporated under reduced pressure. Recrystallization from a mixture of chloroform and hexane gave 31 mg (55.7% yield) of the desired product as purple colored crystals having a melting point of 140°-141° (decomposing) and providing the following analyses:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04885304 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-7009c56fd95b4031b6a350951160e39b |
| Source note | uspto-grants-1989_12 |