HCID 20063014, compound → HCID 18636012, compound

HRID 476711Notes

Reaction equation

HRID 476711 reaction equation
[CH3:1][CH:2]([CH3:36])[CH2:3][CH:4]([C:24](=[O:35])[NH:25][CH:26]([C:31](=[O:34])[NH:32][CH3:33])[CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:5][P:6]([CH2:9][N:10]1[C:14](=[O:15])[C:13]2=[C:16]([N+:20]([O-])=O)[CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:23])(=[O:8])[OH:7]>CO.[Pd]>[NH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]2[C:11]([N:10]([CH2:9][P:6]([CH2:5][CH:4]([C:24](=[O:35])[NH:25][C@H:26]([C:31](=[O:34])[NH:32][CH3:33])[CH2:27][CH:28]([CH3:29])[CH3:30])[CH2:3][CH:2]([CH3:36])[CH3:1])(=[O:7])[OH:8])[C:14](=[O:15])[C:13]=12)=[O:23]

Participants

4

Reactant 1

HCID 20063014HCID 20063014, compound

Product 1

HCID 18636012HCID 18636012, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

75 mg of [4-methyl-2-[[3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl][(3-nitrophthalimido)methyl]phosphinic acid were dissolved in 2.5 ml of methanol containing 0.01 g of 10% palladium-on-charcoal. The mixture was hydrogenated for 3 hours and then filtered. The filtrate was evaporated to give 70 mg of [(3-aminophthalimido)methyl][(RS)-4-methyl-2-[[(S)-3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl]phosphinic acid in the form of a yellow foam.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-f5625e72534d474c96367b59a4d723af
Source dataset
uspto-grants-1989_12
Patent number
US04885283

Reaction notes

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