HRID476713

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78530

Diphenylmaleic anhydride

C16H10O3

结构：CC(=O)O.CCOP(=O)(CN)CC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC

HCID86743561

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(CC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC)CN1C(=O)C(c2ccccc2)=C(c2ccccc2)C1=O

HCID53738006

未命名化合物

收率 80.2%

PROCEDURE

实验过程

In a manner analogous to that described in Example 3(A), from 0.52 g of (aminomethyl)[(RS)-4-methyl-2-[[(S)-3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl]phosphinic acid ethyl ester acetate and 0.34 g of diphenylmaleic anhydride, there was obtained 0.581 g of [(2,3-diphenylmaleimido)methyl][(RS)-4-methyl-2-[[(S)-3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl]phosphinic acid ethyl ester in the form of a yellow-green foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e7083283fb5a4f88a7008cb142dee48a
来源数据集: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04885283
来源说明: uspto-grants-1989_12

反应 SMILES

C(O)(=O)C.[CH2:5]([O:7][P:8]([CH2:28][NH2:29])([CH2:10][CH:11]([C:16](=[O:27])[NH:17][C@H:18]([C:23](=[O:26])[NH:24][CH3:25])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH3:6].[C:30]1([C:36]2=[C:37]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[C:38]([O:40][C:41]2=O)=[O:39])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:5]([O:7][P:8]([CH2:28][N:29]1[C:41](=[O:40])[C:36]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[C:37]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:38]1=[O:39])([CH2:10][CH:11]([C:16](=[O:27])[NH:17][C@H:18]([C:23](=[O:26])[NH:24][CH3:25])[CH2:19][CH:20]([CH3:21])[CH3:22])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH3:6]