HRID476714

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2752592

3,6-Dimethoxyphthalic anhydride

C10H8O5

结构：CC(=O)O.CCOP(=O)(CN)CC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC

HCID86743561

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(CC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC)CN1C(=O)c2c(OC)ccc(OC)c2C1=O

HCID54316219

未命名化合物

收率 50.1%

PROCEDURE

实验过程

In a manner analogous to that described in Example 3(A), from 0.5 g of (aminomethyl)[(RS)-4-methyl-2-[[(S)-3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl]phosphinic acid ethyl ester acetate and 0.27 g of 3,6-dimethyoxyphthalic anhydride, there was obtained 0.325 g of [(3,6-dimethoxyphthalimido)methyl][(RS)-4-methyl-2-[[(S)-3-methyl-1-(methylcarbamoyl)butyl]carbamoyl]pentyl]phosphinic acid ethyl ester in the form of a pale yellow foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5751edeb9a5b4446bfd2cd5bad676f0e
来源数据集: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04885283
来源说明: uspto-grants-1989_12

反应 SMILES

C(O)(=O)C.[CH2:5]([O:7][P:8]([CH2:28][NH2:29])([CH2:10][CH:11]([C:16](=[O:27])[NH:17][C@H:18]([C:23](=[O:26])[NH:24][CH3:25])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH3:6].[CH3:30][O:31][C:32]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[C:34]2[C:35]([O:37][C:38](=O)[C:33]=12)=[O:36]>>[CH2:5]([O:7][P:8]([CH2:28][N:29]1[C:35](=[O:36])[C:34]2=[C:40]([O:43][CH3:44])[CH:41]=[CH:42][C:32]([O:31][CH3:30])=[C:33]2[C:38]1=[O:37])([CH2:10][CH:11]([C:16](=[O:27])[NH:17][C@H:18]([C:23](=[O:26])[NH:24][CH3:25])[CH2:19][CH:20]([CH3:21])[CH3:22])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH3:6]