HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → Ethyl 3-ethoxy-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate | HCID 10934859 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | Ethyl 3-ethoxy-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate | HCID 54402571 | — |
Reaction Steps
A mixture of 2.3 g (8.2 mmol) of ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate, 2 ml of triethyl orthoformate, and 20 ml of acetic anhydride is refluxed for 21/2 hours. The reaction mixture is cooled to room temperature and concentrated to give 2.7 g of the title compound as a red oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04885386 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-d71f6285e8d04eb19ada09670b178061 |
| Source note | uspto-grants-1989_12 |