Sodium Hydroxide → Bismuth(III)(1,4,7-triscarboxymethyl-1,4,7,10tetraazacyclododecane)

HRID 476795Notes

Reaction equation

HRID 476795 reaction equation
[N+]([O-])([O-])=O.[Bi+3:5].[N+]([O-])([O-])=O.[N+]([O-])([O-])=O.[C:14]([CH2:17][N:18]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25][N:24]([CH2:30][C:31]([OH:33])=[O:32])[CH2:23][CH2:22][N:21]([CH2:34][C:35]([OH:37])=[O:36])[CH2:20][CH2:19]1)([OH:16])=[O:15].[OH-].[Na+]>>[C:14]([CH2:17][N:18]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25][N:24]([CH2:30][C:31]([OH:33])=[O:32])[CH2:23][CH2:22][N:21]([CH2:34][C:35]([OH:37])=[O:36])[CH2:20][CH2:19]1)([OH:16])=[O:15].[Bi+3:5]

Participants

4

Reactant 3

HCID 14798Sodium Hydroxide2×HCID 107711Bismuth nitrate2×HCID 1078301,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Product 1

HCID 86743556Bismuth(III)(1,4,7-triscarboxymethyl-1,4,7,10tetraazacyclododecane)

Procedure

50mM Bismuth(III) (1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane) was prepared by combining 24.2 mg of bismuth nitrate with 100μl of 1M 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and 140 μl of acid. The solution was adjusted to pH 3 with dilute sodium hydroxide. The mixture was heated at 88° C. until the bismuth nitrate dissolved (ca. 30 minutes). The solution was adjusted to pH 7.3 with dilute sodium hydroxide and reheated briefly at 88° C. until a small quantity of precipitate was dissolved. On cooling, the solution remained clear.

Workup

  1. dissolutiondissolved (ca. 30 minutes)
  2. customreheated briefly at 88° C. until a small quantity of precipitate
  3. dissolutionwas dissolved
  4. temperatureOn cooling

Sources & evidence

ORD record
ord-e5610701d2d94124896baa328d972cff
Source dataset
uspto-grants-1989_12
Patent number
US04885363

Reaction notes

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