HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzylamine → HCID 54431387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | ((2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate | HCID 7302460 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54431387 | HCID 54431387 | — |
Reaction Steps
A solution of 396 mg of 5'-O-(p-toluenesulphonyl)thymidine and 1.5 ml of 4-chlorobenzylamine in 2 ml of DMF was stirred at 80° C. for 2 hours. The solvent was removed by evaporation and the residue was triturated with diethyl ether. The resulting solid was recrystallized from ethanol to yield 56 mg of 5'-(4-chlorobenzylamino)-5'-deoxythymidine, mp 179°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886785 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-c252c35b259f408e90dc775dd2fe6136 |
| Source note | uspto-grants-1989_12 |