2-Bromobenzylamine → HCID 53683829, compound

Participants

Reaction Conditions

Reaction Steps

2.5 g of 2'-deoxy-5-ethyl-5'-O-(p-toluenesulphonyl)uridine were dissolved in 15 ml of DMF and added to 2-bromobenzylamine. The mixture was heated at 80° C. under nitrogen for 5 hours. The solvent was removed by evaporation and the residue was re-evaporated with toluene to given an oil. This was taken up in 20 ml of water/methanol (1:3) and stored in a refrigerator for 1.5 hours. A solid crystallized out and this was filtered off and washed with water/methanol (1:3) to give 0.99 g of 5'-(2-bromobenzylamino)-2',5'-dideoxy-5-ethyluridine, mp 144°-146° C.

Provenance & Evidence