Water → HCID 19836661, compound

Participants

Reaction Steps

A solution of allyl chloroformate (15 ml) in dry dichloromethane was added at -20° C. under stirring to a solution of N-methylpiperazine (10 g) in the same solvent. After 30 minutes the temperature was let rise to +15° C. and the reaction mixture was poured into water. The organic layer was discarded, 1N NaOH was added to a pH≥7, and the mixture was extracted with dichloromethane. The CH2Cl2 extracts were dried (MgSO4), evaporated, and the resulting oil distilled 118° C. (at 18 mmHg) to yield 4-allyloxycarbonyl-1-methylpiperazine (15.3 g).

Provenance & Evidence