Thionyl Chloride → HCID 14126749, compound

Participants

Reaction Steps

40 ml of thionyl chloride are added dropwise to a solution of 60 g of 2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethanol, prepared in Example 2, in 300 ml of chloroform. When the addition is complete, the reaction mixture is heated under reflux for 5 hours. After return to room temperature, the crystals formed are filtered off, carefully washed with acetone and then dried to give 70 g of 1-chloro-2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethane hydrochloride in the form of crystals melting at 218° C.

Provenance & Evidence