Hydrochloric Acid → HCID 19837128, compound

Participants

Reaction Steps

6.5 g of 3-[2-(1,4-dioxa-8-azaspiro(4,5)decan-8-yl)ethylmercapto]-1,2,4-triazolo(4,3-a)pyridine, prepared in Example 53, are heated under reflux for 10 hours in 200 ml of a 0.5N solution of hydrochloric acid. The reaction mixture is then cooled, rendered basic with a solution of sodium bicarbonate and extracted with chloroform. The chloroform phase is dried over magnesium sulfate and concentrated in vacuo. The residue obtained crystallizes from isopropyl acetate. The crystals are filtered off and dried to give 3.5 g of 3-[2-(4-oxopiperidin-1-yl)ethylmercapto]-1,2,4-triazolo(4,3-a)pyridine in the form of crystals melting at 76°-7° C.

Provenance & Evidence