HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 476962Generated: October 26, 2026
Sulfuric Acid → 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone
https://huagongshe.com/reaction/476962
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Potassium Dichromate | HCID 24502 | — |
| Reactant | 4-(4-Chloro-benzylamino)-cyclohexanol | HCID 13670658 | — |
| Product | 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone | HCID 13670664 | — |
Reaction Steps
23.9 g (0.1 Mol) of 4-[N-(4-chlorobenzyl)-amino]-cyclohexanol are suspended in 125 ml of ice water and 32 ml of concentrated sulphuric acid are added. Then 29.4 g (0.1 Mol) of potassium dichromate are added in 2 batches and the mixture is heated for 5 hours at 50° C. It is then cooled, made alkaline with sodium hydroxide solution and extracted with chloroform. After concentration, a yellowish oily liquid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04886812 |
|---|
| Source dataset | uspto-grants-1989_12 |
|---|
| ORD ID | ord-874c5a08b0844fab87f211f243ad1ec2 |
|---|
| Source note | uspto-grants-1989_12 |
|---|
