HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13670738, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)acetamide | HCID 13670690 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 13670738 | HCID 13670738 | — |
Reaction Steps
To a solution of 4.2 g (0.02 Mol) of 6-acetylamino-2-amino-4,5,6,7-tetrahydro-benzthiazole in 100 ml of absolute tetrahydrofuran are added 2.2 g (0.022 Mol) of triethylamine and 3.1 g (0.022 Mol) of benzoylchloride and the mixture is refluxed for 3 hours. The reaction mixture is mixed with water and extracted with ethyl acetate. The organic phase is concentrated by evaporation. The residue is recrystallized from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886812 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-ff04503f5bd14696add4b84c7106b91f |
| Source note | uspto-grants-1989_12 |