Methyl acetoacetate → HCID 86743568, compound

HRID 476970Notes

Reaction equation

HRID 476970 reaction equation
[F:1][C:2]1([F:11])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[O:3]1.[C:12]([O:18][CH3:19])(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15].[C:20](OC(=O)C)(=O)C>>[F:11][C:2]1([F:1])[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:16](=[CH2:20])[C:14](=[O:15])[CH2:13][C:12]([O:18][CH3:19])=[O:17])=[CH:7][C:5]=2[O:6]1

Participants

4

Reactant 3

HCID 7757Methyl acetoacetateHCID 7918Acetic AnhydrideHCID 741032,2-Difluoro-1,3-benzodioxole

Product 1

HCID 86743568HCID 86743568, compound

Procedure

50 mmol of 5-butyliminomethyl)-2,2-difluoro-1,3-benzodioxole and 50 mmol of methyl acetoacetate are added simultaneously to 80 ml of acetic anhydride and, after brief warming, the mixture is left to stand at room temperature for 24 hours. It is then hydrolyzed with 1 l of ice-water and the oil which has separated out is separated off, diluted with a little methylene chloride, dried and subsequently used as the crude product.

Workup

  1. waitafter brief warming, the mixture is left
  2. customhydrolyzed with 1 l of ice-water and the oil which has separated out
  3. customis separated off
  4. additiondiluted with a little methylene chloride
  5. customdried

Sources & evidence

ORD record
ord-c25924b82fe44db68de0bfb36cb5c9db
Source dataset
uspto-grants-1989_12
Patent number
US04886816

Reaction notes

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