Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methylcatechol → 4-Methyl-1,3-benzodioxole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methylcatechol | HCID 340 | — |
| 반응물 | Dibromomethane | HCID 3024 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Dibromomethane | HCID 3024 | — |
| 생성물 | 4-Methyl-1,3-benzodioxole | HCID 88560 | 111.7% |
반응 단계
400 g of methylene bromide and 50 g of tetrabutylammonium bromide are taken under reflux in a stirred apparatus and a solution of 400 ml of water, 130 g of sodium hydroxide and 200 g of 3-methylpyrocatechol are added dropwise in the course of 5 hours. At the end of the addition, the mixture is subsequently stirred for a further 2 hours, cooled and extracted with methylene chloride. The organic phase is dried and distilled on a column. After first runnings of unreacted methylene bromide, 175 g of 4-methyl-1,3-benzodioxole are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04886816 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-39cf905349a1490b964adf50371d4526 |
| 출처 메모 | uspto-grants-1989_12 |