Butylamine → HCID 14405155, compound

HRID 476979Notes

Reaction equation

HRID 476979 reaction equation
[F:1][C:2]1([F:13])[O:6][C:5]2[CH:7]=[CH:8][C:9]([CH:11]=O)=[CH:10][C:4]=2[O:3]1.[CH2:14]([NH2:18])[CH2:15][CH2:16][CH3:17]>C(Cl)Cl>[CH2:14]([N:18]=[CH:11][C:9]1[CH:8]=[CH:7][C:5]2[O:6][C:2]([F:13])([F:1])[O:3][C:4]=2[CH:10]=1)[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 27369732,2-Difluoro-5-formylbenzodioxole

Product 1

HCID 14405155HCID 14405155, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.10 mol of 2,2-difluoro-5-formyl-1,3-benzodioxole are dissolved in 150 ml of methylene chloride, and 0.12 mol of n-butylamine is added at room temperature, with gentle cooling. The mixture is left to stand at room temperature for 20 hours, without stirring, the solvent is distilled off, together with the water which has separated out, under a slight vacuum, a further 150 ml of methylene chloride are added and are distilled off and the oil which remains is dried under an oil pump vacuum. The butylimino compound can be used in the crude form, for example in Example 2.

Workup

  1. waitThe mixture is left
  2. distillationthe solvent is distilled off, together with the water which
  3. customhas separated out, under a slight vacuum
  4. additiona further 150 ml of methylene chloride are added
  5. distillationare distilled off
  6. customthe oil which remains is dried under an oil pump vacuum

Sources & evidence

ORD record
ord-b43cd20f9ef3440a978b39b56dfb3b2c
Source dataset
uspto-grants-1989_12
Patent number
US04886816

Reaction notes

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