Maleate(2-) → HCID 70385864, compound

HRID 476991Notes

Reaction equation

C([O-])(=O)/C=C\[C:4]([O-:6])=[O:5].C[O:10][C:11](=[O:39])[C@@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:38])[C@H:18]([CH3:37])[NH:19][C@H:20](OCC)[C:21](=C=O)[S:22][CH:23]1[CH2:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24]1>>[C:4]([C@@H:20]([NH:19][C@H:18]([C:17]([N:13]1[CH2:14][CH2:15][CH2:16][C@H:12]1[C:11]([OH:10])=[O:39])=[O:38])[CH3:37])[CH2:21][S:22][CH:23]1[CH2:24][C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:31]1)([OH:6])=[O:5]

Participants

Reactant 2

HCID 5288227Maleate(2-)

HCID 86743571HCID 86743571, compound

Product 1

HCID 70385864HCID 70385864, compound

Procedure

Following the general procedure of Example 59, the title compound was prepared as white crystals from 300 mg of the maleate of β-isomer of N-[(R)-1-ethoxy-carbonyl-2(2-indanyl)thioethyl]-alanyl-(S)-proline methyl ester prepared in Example 58. Yield 165 mg.

Sources & evidence

ORD record: ord-6baa180d65b1433995742ceb131ed1ef
Source dataset: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04886813

Reaction notes

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