HuagongsheHuagongshe Chemistry Print Report · For research reference only
rel-(2R,6S)-2,6-dimethylpiperazine → Orbifloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | 1-Cyclopropyl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13825515 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Orbifloxacin | HCID 60605 | — |
Reaction Steps
In the same manner as described in Example 1, a mixture of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, cis-2,6-dimethylpiperazine, and dimethylformamide was stirred at room temperature for 24 hours to give 1-cyclopropyl-5,6,8-trifluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, which was recrystallized from chloroform-ethanol, m.p. 259°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886810 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-ea9b679f6eff4b07904d63cb20e70c60 |
| Source note | uspto-grants-1989_12 |