反应详情

温度

50 °C

A mixture of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.8 g), 3-amino-3-methylpyrrolidine (0.8 g), and acetonitrile (35 ml) was stirred at 50° C. for 30 minutes. The precipitated crystals were collected by filtration, and washed with water. The crystals were dissolved in 10% aqueous ammonia, treated with activated carbon, and concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with water and dried to give 7-(3-amino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-4-oxoquinoline 3-carboxylic acid (0.81 g), m.p. 280°-282° C.

1. filtrationThe precipitated crystals were collected by filtration
2. washwashed with water
3. dissolutionThe crystals were dissolved in 10% aqueous ammonia
4. additiontreated with activated carbon
5. concentrationconcentrated under reduced pressure
6. filtrationThe precipitated crystals were collected by filtration
7. washwashed with water
8. customdried