1-Cyclopropyl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 14304608, compound

Participants

Reaction Steps

A mixture of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.32 g), cis-3-trifluoroacetylamino-4-fluoromethylpyrrolidine (1.41 g), and pyridine (10 ml) was refluxed for 5 hours. The reaction mixture was concentrated to dryness under reduced pressure. Water was added to the residue, and the resulting precipitate were collected. Recrystallization from dimethylformamide gave 1-cyclopropyl-5,6,8-trifluoro-7-(cis-3-trifluoroacetylamino-4-fluoromethyl-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.25 g), m.p. 283°-284° C.

Provenance & Evidence