HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 70395651, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13910947 | — |
| Reactant | HCID 70396196 | HCID 70396196 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 70395651 | HCID 70395651 | 56% |
Reaction Steps
A mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.36 g), trans-3-methoxycarbonylamino-4-ethyl pyrrolidine (0.94 g), diisopropylethylamine (0.88 g), and acetonitrile (20 ml) was refluxed for 15 hours. The precipitated crystals wee collected by filtration, and dried to give 5-amino-1-cyclopropyl-7-(trans-3-methoxycarbonylamino-4-ethyl-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.15 g), recrystallized from chloroform-ethanol, m.p. 231°-232° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886810 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-6142b69b936b49ffaf42c5ea7536e7cb |
| Source note | uspto-grants-1989_12 |