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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 477023Generated: October 30, 2026

Diisopropylethylamine → HCID 15729386, compound

https://huagongshe.com/reaction/477023

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
Reactant5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 13910947—
ReactantHCID 15729377HCID 15729377—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 15729386HCID 15729386—

Reaction Steps

In the same manner as described in Example 13 (1), a mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro1,4-dihydro-4-oxoquinoline-3-carboxylic acid, cis-3-trifluoroacetylamino-4-fluoromethylpyrrolidine, diisopropylethylamine, and dioxane was refluxed for 12 hours to give 5-amino-7-(cis-3-trifluoroacetylamino4-fluoromethyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04886810
Source datasetuspto-grants-1989_12
ORD IDord-4260ca2cb405436fbde3f47efcaec25d
Source noteuspto-grants-1989_12