HCID 1516512, compound → HCID 70395241, compound

Participants

Reaction Steps

A mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.22 g), cis-3-aminomethyl-4-methylpyrrolidine (1.68 g), and acetonitrile (30 ml) was refluxed for 4.5 hours. The reaction mixture was concentrated to dryness under reduced pressure. The resulting crude crystals were recrystallized from ethanol to give 5-amino-7-(cis-3-aminomethyl-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.3 g), recrystallized from ethanol-chloroform, m.p. 221°-223° C.

Provenance & Evidence