HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 477080Generated: October 25, 2026
Hydrogen Bromide → 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone
https://huagongshe.com/reaction/477080
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(2,5-Dimethyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14738583 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone | HCID 14076232 | — |
Reaction Steps
2.8 g (0.02 mol) of 2,5-Dimethyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 35% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 100° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 2 hours the solvent is removed, and the residue is triturated with 50 ml of ether and filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04886814 |
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| Source dataset | uspto-grants-1989_12 |
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| ORD ID | ord-68dedfacc2014f55aebfa61493da6dbe |
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| Source note | uspto-grants-1989_12 |
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